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R.J. Reynolds Tobacco Company (R.J. Reynolds) is the second-largest tobacco company in the United States, manufacturing about one of every three cigarettes sold in the country.

American Snuff Company, LLC is the nation's second-largest manufacturer of smokeless tobacco products. American Snuff Co. also sells and distributes a variety of tobacco products manufactured by Lane, Limited, including little cigars and roll-your-own tobacco.

Santa Fe Natural Tobacco Company, Inc. manufactures Natural American Spirit additive-free tobacco products.

Niconovum AB markets nicotine replacement therapy (NRT) products under the Zonnic brand name in Sweden and Denmark. Its nicotine gum, mouth spray and pouches use proprietary technology for nicotine delivery.